| Date | Opponent | USC Upstate Notes | Opponent Notes | Atlantic Sun Notes |
| 11/11 | at Arkansas | Upstate | Arkansas | A-Sun |
| 11/14 | Piedmont College | Upstate | N/A |
A-Sun |
| 11/18 | &at Texas-Pan American | Upstate | N/A |
A-Sun |
| 11/19 | &vs. Toledo | Upstate | Toledo | A-Sun |
| 11/20 | &vs. Texas State | Upstate | Texas State | A-Sun |
| 11/25 | Texas-Pan American | Upstate | Texas-Pan American | A-Sun |
| 11/27 | &Victory University | Upstate | N/A | A-Sun |
| 12/1 | Jacksonville State | Upstate | Jacksonville State | A-Sun |
| 12/4 | at UNC Asheville | Upstate | UNC Asheville | A-Sun |
| 12/11 | at Dayton | Upstate | Dayton | A-Sun |
| 12/14 | at No. 2 Ohio State | Upstate | Ohio State | A-Sun |
| 12/17 | *at Stetson | Upstate | Stetson | A-Sun |
| 12/19 | *at Florida Gulf Coast | Upstate | Florida Gulf Coast | A-Sun |
| 12/31 | at South Carolina | Upstate | South Carolina | N/A |
| 1/4 | *at ETSU | Upstate | ETSU | N/A |
| 1/7 | *Kennesaw State | Upstate | Kennesaw State | A-Sun |
| 1/9 | *Mercer | Upstate | Mercer | A-Sun |
| 1/14 | *at North Florida | Upstate | North Florida | A-Sun |
| 1/16 | *at Jacksonville | Upstate | Jacksonville | A-Sun |
| 1/21 | *Belmont | Upstate | Belmont | A-Sun |
| 1/23 | *Lipscomb | N/A | Lipscomb | A-Sun |
| 1/27 | *ETSU | Upstate | ETSU | A-Sun |
| 1/30 | at Jacksonville State | Upstate | Jacksonville State | A-Sun |
| 2/4 | *at Mercer | Upstate | N/A | A-Sun |
| 2/6 | *at Kennesaw State | Upstate | Kennesaw State | A-Sun |
| 2/11 | *Jacksonville | Upstate | Jacksonville | A-Sun |
| 2/13 | *North Florida | Upstate | North Florida | A-Sun |
| 2/18 | *at Lipscomb | Upstate | Lipscomb | A-Sun |
| 2/20 | *at Belmont | Upstate | Belmont | A-Sun |
| 2/23 | *Florida Gulf Coast | Upstate | Florida Gulf Coast | A-Sun |
| 2/25 | *Stetson | Upstate | Stetson | A-Sun |
| 3/1 | $ (6) Florida Gulf
Coast |
Upstate | Florida Gulf Coast |
A-Sun |
| 3/15 | % Kent State |
Upstate |
Kent State |
A-Sun |
| 3/18 | %at Old Dominion | Upstate |
Old Dominion |
A-Sun |
* - A-Sun Conference Game
$ - A-Sun Tournament (University Center - Macon,
Ga.)
% - CollegeInsider.com Tournament
& - UTPA Tip-Off Classic (Edinburg, Texas / Spartanburg, S.C.)